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NABP NAPLEX Exam - Topic 6 Question 110 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 110
Topic #: 6
[All NAPLEX Questions]

Which of the following would be most appropriate to treat infections associated with stenotrophomonas maltophilia?

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Suggested Answer: D

Primary treatment for stenotrophomonas maltophilia is SMX-TMP. Meropenem, ciprofloxacin, Ampicillin and vancomycin have no coverage.


by Carla at Aug 16, 2025, 04:04 AM

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Jesus
2 months ago
Vancomycin won't work for this, just FYI!
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Rozella
2 months ago
Really? I didn't know that, sounds surprising!
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Mozell
2 months ago
I thought meropenem was effective too?
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Dacia
3 months ago
Totally agree, it's one of the few effective options!
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Corrie
3 months ago
Sulfamethoxazole/trimethoprim is usually the go-to for S. maltophilia.
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Hubert
3 months ago
I have a vague memory that vancomycin wouldn't work here since it's more for Gram-positive infections. I think I should lean towards sulfamethoxazole/trimethoprim.
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Lauryn
3 months ago
I practiced a question similar to this, and I think ciprofloxacin was mentioned as an option, but I don't recall it being the best choice for this specific infection.
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Sheridan
4 months ago
I’m not entirely sure, but I feel like meropenem is not effective against this organism. I might be mixing it up with other Gram-negative bacteria.
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Mattie
4 months ago
I think I remember that Stenotrophomonas maltophilia is often resistant to many antibiotics, but isn't sulfamethoxazole/trimethoprim usually the go-to treatment?
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Ilda
4 months ago
I'm pretty confident on this one. Stenotrophomonas is an opportunistic pathogen that can cause serious infections, especially in immunocompromised patients. The treatment of choice is typically sulfamethoxazole/trimethoprim, so I'll select option D.
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Cordelia
4 months ago
Wait, is Stenotrophomonas the same as Pseudomonas? I'm getting a bit mixed up here. Maybe I should review my notes on gram-negative bacteria before answering this.
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Michell
4 months ago
Okay, I've got this. Stenotrophomonas is often resistant to many common antibiotics, but sulfamethoxazole/trimethoprim and fluoroquinolones like ciprofloxacin are usually good choices. I'll go with option D.
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Florinda
4 months ago
Hmm, I'm a bit unsure about this one. I know Stenotrophomonas can be tricky to treat, but I can't quite remember the preferred antibiotic options off the top of my head. I'll have to think this through carefully.
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Kati
5 months ago
This seems like a straightforward question about antibiotic treatment for Stenotrophomonas maltophilia infections. I'll need to recall what I know about the typical susceptibility patterns for this organism.
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