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NABP NAPLEX Exam Questions
- Topic 1: Foundational Knowledge for Pharmacy Practice: This section of the exam measures skills of Pharmacists and covers essential pharmaceutical sciences that support safe and effective patient care. It includes principles of pharmacology, pharmacokinetics, pharmacodynamics, and pharmaceutics. Candidates must understand pharmaceutical compounding for both sterile and nonsterile preparations, perform accurate calculations for doses and concentrations, and interpret biostatistical and pharmacoeconomic data. Additionally, knowledge of drug development, clinical trials, and critical evaluation of medical literature is assessed.
- Topic 2: Medication Use Process (Prescribing, Transcribing, Documenting, Dispensing, Administering, and Monitoring): This section of the exam measures skills of Clinical Pharmacists and evaluates their ability to manage the complete medication use process. It focuses on interpreting prescriptions, understanding drug indications and dosing, ensuring compliance with regulations, and monitoring patient safety and drug effectiveness. It also assesses the ability to handle therapeutic substitutions, immunization protocols, and proper drug storage, stability, and disposal. Mastery of safety measures in managing hazardous substances is essential.
- Topic 3: Person-Centered Assessment and Treatment Planning: This section of the exam measures skills of Clinical Pharmacy Practitioners and covers patient-centered care, including collecting and evaluating medication and health histories. It requires understanding disease pathophysiology, identifying medication-related problems, and ensuring therapy appropriateness. Candidates must demonstrate ability to monitor therapy outcomes, detect drug interactions and adverse effects, and modify treatment plans based on clinical goals. This section also includes patient counseling, health education, adherence support, and proper use of devices for self-monitoring.
- Topic 4: Professional Practice: This section of the exam measures skills of Pharmacy Professionals and emphasizes ethical and regulatory responsibilities within pharmacy practice. It includes adverse event and medication error reporting, participation in public health initiatives like antimicrobial and opioid stewardship, and understanding social determinants of health. Candidates must demonstrate ethical decision-making, patient confidentiality, and adherence to professional conduct standards when delivering pharmaceutical care.
- Topic 5: Pharmacy Management and Leadership: This section of the exam measures the skills of Pharmacy Managers and focuses on operational leadership in pharmacy practice. It includes topics like workflow planning, risk management, quality improvement, and medication safety systems. Candidates are assessed on managing inventory, handling drug recalls, and implementing continuous improvement processes. Leadership skills such as mentoring, delegation, and fostering professional development within teams are also evaluated to ensure effective pharmacy operations.
Free NABP NAPLEX Exam Actual Questions
Note: Premium Questions for NAPLEX were last updated On May. 16, 2026 (see below)
An 18-year-old female is referred to a dermatologist for treatment of severe acne vulgaris. The dermatologist wants to start her on tetracycline.
What test should the patient have prior to starting treatment?
Pregnancy test. Tetracyclines are effective in the treatment of severe cases of acne. They are however teratogenic. As such, it is imperative to make sure female patients are not pregnant prior to starting this medication. In many instances patients are started on concurrent birth control to mitigate this risk even further.
A chest x-ray (B) is an important exam to obtain prior to starting drugs which have pulmonary toxicity as a side effect such as amiodarone. A complete blood count (C) would be useful prior to starting a medication that causes anemia, such as immunosuppressive and chemotherapeutic agents. Liver function tests (D) are important to establish as a baseline prior to starting anti-mycobacterial agents. Creatine kinase levels (E) are used to establish as a baseline prior to starting statins.
Which of the following would be most appropriate to treat stenotrophomonas maltophilia?
Primary treatment for stenotrophomonas maltophilia is SMX-TMP. Meropenem, ciprofloxacin, and vancomycin have no coverage.
Alteplase is ordered for a 72 YOM who weighs 68kg for Ischemic stroke. The ER physician would like you to dose. As an ER pharmacist you know the dose is 0.9 mg/kg IV (not to exceed 90 mg); give 10% of the total dose as an IV bolus over 1 minute, then give the remaining 90% as an IV infusion over 60 minutes. After reconstitution, the concentration of Altaplace is 1mg/ml. How many ml is needed for the bolus and how many ml is needed for the infusion? Round to the nearest ml.
68kg 0.9mg/kg = 61.2mg dose 1mg/mL = 61.2mL 61.2mg 0.1 = 6mL IV bolus 61.2mg 0.9 = 55mL IV over 60 minutes
Your patient, a 25-year-old G1P0 female at 26 weeks gestation presents due to an abnormal glucose tolerance test. One week prior, she was given 50 g of oral glucose and demonstrate a venous plasma glucose level of 156 mg/dL one hour later.
Which of the following is the most appropriate next step of management?
Gestational diabetes is typically asymptomatic but identified via a 1-hour 50g oral glucose challenge administered at 24--28 weeks of gestation. A venous plasma glucose blood level of > 140 mg/dL is suggestive, and must be confirmed with a 3-hour 100g oral glucose tolerance test. After administration of the 100g glucose challenge, at least two of the following are required for diagnosis: (1) fasting glucose > 95 mg/dL, (2) one-hour glucose >180 mg/dL, (3) two hour glucose >155 mg/dL, and (4) three hour glucose > 140 mg/dL. Choice A --
To diagnose gestational diabetes, a positive 1-hour 50g oral glucose challenge must be followed up by a three-hour 100g oral glucose challenge. The diagnosis is only confirmed after both challenges are completed and the thresholds are met. Choice C -- Following the diagnosis of gestational diabetes, the first step is strict glycemic control (fasting glucose).
An order is received to start Milrinone at 0.75mcg/kg/min, Milrinone comes as 20mg/100ml D5W. What is the infusion rate in mL/hr? Patient weighs 115kg.
Patient dose: 0.75mcg 115kg = 86.25mcg/min (100mL/20mg) (86.25mcg/1hr) (60min/1hr) (1mg/1000mcg) = 25.875mL/hr Rate of infusion of Milrinone
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