NABP Exam NAPLEX Topic 1 Question 16 Discussion

Actual exam question for NABP's North American Pharmacist Licensure Examination exam

Question #: 16
Topic #: 1

[All North American Pharmacist Licensure Examination Questions]

A physician needs your help to calculate the protamine dose on a patient who started hemorrhaging while on heparin. Patient has been receiving heparin at a dose of 13mls/hr for 2 hrs when the physician decides to use protamine to reverse the heparin. Heparin bag says concentration of 50 units/ml. The half-life of heparin is 60 minutes. 1 mg of protamine reverses 100 units of heparin.

How much protamine should be given to this patient?

A5mg

B10mg

C7mg

D13mg

E9.7mg

Show Suggested Answer

Suggested Answer: E

1st hour: 13mL/hr 1 hr = 13mL 50U/mL = XU/13mL 650U Heparin given in hours since the half-life of protamine is 60 min 2nd hour 650/2 =325 units 650 units + 325 units = 975 units needs to be reversed.

**1mg of protamine reverses 100U of Heparin (1mg protamine/100U Heparin) = (x mg protamine/975U Heparin given) = x = 9.7mg protamine

by Ma at May 04, 2022, 07:03 AM

Limited Time Offer

25%

Off

Get Premium NAPLEX Questions as Interactive Web-Based Practice Test or PDF

Contribute your Thoughts:

Submit Cancel

Currently there are no comments in this discussion, be the first to comment!