Beta-Thalassemia Major and Splenectomy:

Patients with beta-thalassemia major often require frequent blood transfusions.

Splenectomy increases the risk of infections due to loss of the spleen's immune function.

Priority Nursing Interventions:

Prevent Infections: The highest priority post-splenectomy due to the increased risk of sepsis and other infections.

High-Fat Intake, Frequent Voiding, Hydration: Important but secondary to infection prevention.

Centers for Disease Control and Prevention (CDC) guidelines on post-splenectomy care

National Institutes of Health (NIH) on Thalassemia Management