Elevation of alpha-fetoprotein levels is a characteristic finding in which tumor?
Alpha-fetoprotein (AFP) is commonly elevated in patients with hepatocellular carcinoma (hepatoma), particularly in those with underlying cirrhosis or chronic hepatitis B/C. AFP is not typically elevated in adenomas, cholangiocarcinoma, or FNH.
According to Rumack's Diagnostic Ultrasound:
''Serum AFP levels are elevated in 50--70% of patients with hepatocellular carcinoma.''
Rumack CM, Wilson SR, Charboneau JW, Levine D. Diagnostic Ultrasound. 5th ed. Elsevier, 2017.
AASLD Guidelines for HCC Surveillance, 2018.
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Where in the neck are most thyroid cancer recurrences found?
Most thyroid cancer recurrences are found in the ipsilateral neck---particularly in the central (level VI) or lateral (levels II-V) compartments on the same side as the original malignancy.
According to AIUM Practice Parameters:
''Post-thyroidectomy recurrence most frequently occurs ipsilateral to the original tumor, commonly involving regional lymph nodes.''
AIUM Practice Parameter for Thyroid and Neck Ultrasound, 2020.
American Thyroid Association (ATA) Guidelines for Thyroid Cancer Management, 2015.
Which technique would best assist the sonographer to verify the finding in this image obtained from the right upper quadrant?

The image demonstrates a gallbladder with a possible echogenic focus (likely a gallstone) and posterior acoustic shadowing. This is suggestive of cholelithiasis. To differentiate uncomplicated gallstones from acute cholecystitis, the most effective technique is to assess for a positive sonographic Murphy sign.
A positive sonographic Murphy sign refers to the presence of focal tenderness over the gallbladder when it is directly palpated with the ultrasound transducer. It is a strong indicator of acute cholecystitis when combined with other features such as gallbladder wall thickening, pericholecystic fluid, and gallstones.
Sonographic Murphy sign --- key points:
Assessed during real-time scanning
Localized tenderness when pressure is applied over the gallbladder
Highly sensitive for acute cholecystitis (especially in the presence of stones)
Differentiation from other options:
A . Use compound imaging: Improves image quality by reducing artifacts but does not verify tenderness or confirm acute inflammation.
B . Change the patient's position: Helpful to confirm mobility of gallstones, but not diagnostic of inflammation.
C . Ask patient to perform Valsalva: Used primarily in vascular studies (e.g., assessing for varicocele or venous reflux), not relevant here.
Rumack CM, Wilson SR, Charboneau JW, Levine D. Diagnostic Ultrasound. 5th Edition. Elsevier, 2018. Chapter: Gallbladder and Biliary System, pp. 148--152.
AIUM Practice Parameter for the Performance of an Ultrasound Examination of the Abdomen and/or Retroperitoneum, 2020.
Radiopaedia.org. Sonographic Murphy sign: https://radiopaedia.org/articles/sonographic-murphy-sign
Which description is associated with the normal sonographic appearance of a tendon?
On ultrasound, tendons appear as cord-like hyperechoic structures with linear fibrillar echotexture when imaged in long axis. The fibrils are highly reflective, creating the typical hyperechoic appearance. Posterior shadowing is not typical unless there is calcification.
According to Rumack's Diagnostic Ultrasound:
''Tendons have a highly organized hyperechoic linear fibrillar pattern when examined along their long axis.''
Rumack CM, Wilson SR, Charboneau JW, Levine D. Diagnostic Ultrasound. 5th ed. Elsevier, 2017.
AIUM Practice Parameter for Musculoskeletal Ultrasound, 2020.
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Which is the most likely etiology of a spherical mass near the splenic hilum that is isoechoic to the normal spleen in a 55-year-old female?
An accessory spleen (splenule) is a congenital variant, commonly located near the splenic hilum, and has identical echogenicity to the native spleen. This finding is benign and often incidental.
According to Rumack's Diagnostic Ultrasound:
''Accessory spleens are typically found near the splenic hilum and are isoechoic to the normal splenic parenchyma.''
Rumack CM, Wilson SR, Charboneau JW, Levine D. Diagnostic Ultrasound. 5th ed. Elsevier, 2017.
AIUM Practice Parameter for Abdominal Ultrasound, 2020.
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