Discuss OMSB OMSB_OEN Exam Topic 3 Question 45

A woman presents to the clinic with signs and symptoms of menopause. The doctor advised to start hormonal replacement therapy. The woman enquired about the adverse effects of this therapy.

Which of the following is an adverse effects of the hormonal replacement therapy?

AOsteoporosis

BAtherosclerosis

CEndometrial cancer

DCerebrovascular accident

Suggested Answer: C

Hormone replacement therapy (HRT) can have several adverse effects. One significant risk associated with HRT, especially if estrogen is given without progesterone to women with an intact uterus, is the increased risk of endometrial cancer. Estrogen stimulates the lining of the uterus, and without the balancing effect of progesterone, this can lead to endometrial hyperplasia and potentially cancer. Other risks include breast cancer, blood clots, and stroke, but endometrial cancer is a specific concern with unopposed estrogen therapy.

Goodman, N. F., et al. (2011). American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of menopause. Endocrine Practice, 17(6), 1-25.

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17 comments · newest first

Vicente 5 days ago

Definitely! Informed decisions are crucial.

Felton 10 days ago

Overall, patients need to weigh the risks carefully.

Annelle 15 days ago

Exactly! D) Cerebrovascular accident is less common but still possible.

Vicente 20 days ago

Right, and osteoporosis is usually a concern after menopause, not from HRT itself.

Felton 26 days ago

True, but C is more directly linked to HRT.

Annelle 1 month ago

But what about B) Atherosclerosis? That’s also a serious risk.

Vicente 1 month ago

Yeah, I agree. It can increase the risk.

Felton 1 month ago

I think C) Endometrial cancer is a big concern with HRT.

Benton 2 months ago

Totally agree, C) Endometrial cancer is a big concern with HRT.

Leonardo 2 months ago

Wait, are we sure about D) Cerebrovascular accident? Sounds a bit extreme.

Aron 2 months ago

Definitely B) Atherosclerosis, I've read about that.

Jill 2 months ago

I thought HRT was supposed to help with osteoporosis?

Chauncey 2 months ago

C) Endometrial cancer is a known risk.

Junita 2 months ago

I vaguely remember that HRT can lead to an increased risk of cerebrovascular accidents, but I’m not confident. I should probably double-check that before answering.

Pa 3 months ago

I feel like we had a practice question about the risks of HRT, and I think osteoporosis was mentioned as a benefit rather than an adverse effect. So, I don’t think A is correct.

Annabelle 3 months ago

I’m not entirely sure, but I think atherosclerosis could be a concern with HRT. We talked about cardiovascular risks in class, but I can't recall the specifics.

Mattie 3 months ago

I remember discussing that hormonal replacement therapy can increase the risk of certain cancers, especially endometrial cancer. So, I think C might be the right answer.

OMSB_OEN Exam - Topic 3 Question 45 Discussion