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NCLEX Exam NCLEX-PN Topic 1 Question 5 Discussion

Actual exam question for NCLEX's NCLEX-PN exam
Question #: 5
Topic #: 1
[All NCLEX-PN Questions]

The chemotherapeutic DNA alkylating agents such as nitrogen mustards are effective because they:

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Suggested Answer: A

Alkylating agents are highly reactive chemicals that introduce alkyl radicals into biologically active molecules

and thereby prevent their proper functioning, replication, and transcription. Choice 2 is incorrect because alkylating

agents have numerous side effects including alopecia, nausea, vomiting, and myelosuppression. Choice 3 is incorrect because nitrogen mustards have a broad spectrum of activity against chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and breast and ovarian cancer, but they are effective chemotherapeutic agents because of DNA crosslinkage. Choice 4 is incorrect because alkylating agents are non-cell-cycle-specific agents.PharmacologicalTherapies


by Lajuana at Jun 12, 2025, 08:59 PM

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Weldon
18 days ago
A is the clear winner here. Alkylating the DNA is their main mode of action in killing cancer cells.
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Veta
10 days ago
A) cross-link DNA strands with covalent bonds between alkyl groups on the drug and guanine bases on DNA.
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Gussie
22 days ago
Haha, B is a good one. 'Few, if any, side effects' - yeah, right! These chemotherapies are notorious for their nasty side effects.
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Gianna
13 days ago
A) cross-link DNA strands with covalent bonds between alkyl groups on the drug and guanine bases on DNA.
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Lera
27 days ago
Definitely A. Crosslinking DNA is the key mechanism of action for these alkylating agents.
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Dominga
4 days ago
Definitely A. Crosslinking DNA is the key mechanism of action for these alkylating agents.
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Sunny
6 days ago
A) cross-link DNA strands with covalent bonds between alkyl groups on the drug and guanine bases on DNA.
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Angelica
1 months ago
I think A is the right answer. The ability to form covalent bonds with DNA is what makes these agents potent against cancer cells.
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Mollie
18 days ago
Yes, A is the right choice. The alkylating agents work by forming covalent bonds with DNA, leading to cell death.
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Dorothy
24 days ago
I think it's A too. The cross-linking of DNA strands is what causes damage to the cancer cells.
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Veronika
28 days ago
I agree, A is the correct answer. The covalent bonds with DNA are crucial for their effectiveness.
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Rebbeca
1 months ago
I'm not sure, but I think A makes sense based on what we learned in class.
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Tawna
1 months ago
I agree with Alfreda, because cross-linking DNA strands can prevent cell division.
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Patria
2 months ago
The correct answer is A. The alkylating agents cross-link DNA strands, which is why they are effective in chemotherapy.
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Selene
26 days ago
The alkylating agents cross-link DNA strands, which is why they are effective in chemotherapy.
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Giuseppe
1 months ago
A) cross-link DNA strands with covalent bonds between alkyl groups on the drug and guanine bases on DNA.
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Alfreda
2 months ago
I think the answer is A.
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