NABP NAPLEX Exam - Topic 5 Question 118 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 118
Topic #: 5

Alteplase is ordered for a 72 YOM who weighs 68kg for Ischemic stroke. The ER physician would like you to dose. As an ER pharmacist you know the dose is 0.9 mg/kg IV (not to exceed 90 mg); give 10% of the total dose as an IV bolus over 1 minute, then give the remaining 90% as an IV infusion over 60 minutes. After reconstitution, the concentration of Altaplace is 1mg/ml. How many ml is needed for the bolus and how many ml is needed for the infusion? Round to the nearest ml.

A6ml IV bolus, followed by 55mL IV over 60 minutes

B4ml IV bolus, followed by 57mL IV over 60 minutes

C3ml IV bolus, followed by 58mL IV over 60 minutes

D8ml IV bolus, followed by 52mL IV over 60 minutes

E9ml IV bolus, followed by 82mL IV over 60 minutes

Show Suggested Answer

Suggested Answer: A

68kg 0.9mg/kg = 61.2mg dose 1mg/mL = 61.2mL 61.2mg 0.1 = 6mL IV bolus 61.2mg 0.9 = 55mL IV over 60 minutes

by Paola at Apr 12, 2026, 04:58 AM

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2 months ago

I remember the dosing for alteplase is 0.9 mg/kg, but I'm not sure how to calculate the bolus and infusion volumes correctly.

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