NABP NAPLEX Exam - Topic 8 Question 52 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 52
Topic #: 8

Alteplase is ordered for a 72 YOM who weighs 68kg for Ischemic stroke. The ER physician would like you to dose. As an ER pharmacist you know the dose is 0.9 mg/kg IV (not to exceed 90 mg); give 10% of the total dose as an IV bolus over 1 minute, then give the remaining 90% as an IV infusion over 60 minutes. After reconstitution, the concentration of Altaplace is 1mg/ml. How many ml is needed for the bolus and how many ml is needed for the infusion? Round to the nearest ml.

A6ml IV bolus, followed by 55mL IV over 60 minutes

B4ml IV bolus, followed by 57mL IV over 60 minutes

C3ml IV bolus, followed by 58mL IV over 60 minutes

D8ml IV bolus, followed by 52mL IV over 60 minutes

E9ml IV bolus, followed by 82mL IV over 60 minutes

Show Suggested Answer

Suggested Answer: A

68kg 0.9mg/kg = 61.2mg dose 1mg/mL = 61.2mL 61.2mg 0.1 = 6mL IV bolus 61.2mg 0.9 = 55mL IV over 60 minutes

by Theodora at Sep 22, 2022, 03:10 AM

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Lilli

4 months ago

9 mL for the bolus? That sounds way too high!

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Nathan

4 months ago

I calculated it too, and I'm getting 57 mL for the infusion.

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Angella

4 months ago

Wait, how do we get 55 mL for the infusion? Seems off.

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Pilar

4 months ago

I think it's definitely option A, that makes the most sense!

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Adolph

4 months ago

The dose is 0.9 mg/kg, so that's 61.2 mg total.

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Tegan

5 months ago

I feel like I might have mixed up the bolus and infusion amounts in my practice questions. I hope I remember the 90% for the infusion correctly!

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Veronika

5 months ago

If the patient is 68 kg, that would be 61.2 mg total, right? So, I think the bolus should be around 6 ml, but I need to double-check my math.

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German

5 months ago

I practiced a similar question on alteplase dosing last week, and I think the bolus is 10% of the total dose.

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Heike

5 months ago

I remember the dosing for alteplase is based on weight, but I'm a bit unsure about the exact calculations for the bolus and infusion.

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Shelia

5 months ago

This is a tough one, but I'm pretty confident the right answer is to resign. We have to maintain our independence and integrity as fraud examiners, even if it means walking away from the job.

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Erick

5 months ago

I remember studying about visual service development tools, but they seem more focused on the creation side rather than discovery and governance.

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Emilio

5 months ago

I've got a good strategy for this - I'll quickly review what I know about each of those organizations and see which one fits best as an example of a trade agreement. That should help me nail down the right answer.

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Micaela

5 months ago

I'm a bit confused by the wording of this question. What exactly is "tor blockchain data"? Is that referring to some specific type of blockchain data? I'll need to do some quick research on that before I can confidently select an answer.

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