NABP NAPLEX Exam - Topic 8 Question 38 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 38
Topic #: 8

Results from a Meta-analysis where they looked at frequency of postoperative arterial fibrillation in patients on Ascorbic acid after cardiac surgery found odds ratio, 0.44 (95% CI, 0.32 to 0.61). How can you interpret this data?

AAscorbic acid increased frequency of postoperative arterial fibrillation after cardiac surgery by 44%

BAscorbic acid decreased frequency of postoperative arterial fibrillation after cardiac surgery by 44%

CThere was no statistically significant difference in frequency of postoperative arterial fibrillation after cardiac surgery

DAscorbic acid decreased frequency of postoperative arterial fibrillation after cardiac surgery by 56%

ENone of the above are correct

Show Suggested Answer

Suggested Answer: D

Odds ratio of 0.44 (44%) means that this group was associated with an event happening 44% of the time, compared to 1 (an event happening 100% of the time if unexposed), therefore 100 - 44 = 56%, which is the reduction caused by the exposure. Exposure is the use of ascorbic acid.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112884/

by Cristal at May 05, 2022, 07:05 PM

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Wendell

4 months ago

So glad to see Ascorbic acid helping post-surgery!

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Denae

4 months ago

Not sure about this, seems too good to be true.

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Kimbery

4 months ago

Wait, how does that translate to a 56% decrease? Sounds off.

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Judy

4 months ago

I agree, definitely a reduction in frequency.

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Britt

5 months ago

The odds ratio of 0.44 means a decrease, not an increase!

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Barrie

5 months ago

I think option D is wrong because the odds ratio doesn't translate directly to a percentage like that. It’s definitely less than 1, but I’m not sure about the exact interpretation.

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Ruth

5 months ago

I feel like I saw something similar in our lectures, but I can't recall if it was about a percentage decrease or just a general reduction.

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Elvera

5 months ago

I'm not entirely sure, but I think the odds ratio of 0.44 suggests a significant reduction. I might be confusing it with another practice question we did.

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Brianne

5 months ago

I remember that an odds ratio less than 1 indicates a decrease in the outcome, so I think Ascorbic acid might be reducing the frequency of postoperative arterial fibrillation.

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Sylvie

5 months ago

I'm a little confused by the terminology here. I'll need to review my notes to make sure I understand the difference between earned surplus and the other options.

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Jovita

5 months ago

Okay, I think I know the answer to this one. The key is using an application user, not the main admin account, and making sure it has the right permissions.

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Marshall

5 months ago

This seems similar to that practice question where we had to check session traces for endpoint issues. I think option B, executing a session trace, might be the best way to see where the access is breaking down.

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