Discuss NABP NAPLEX Exam Topic 6 Question 19

Which of the following are complication associated with long term use of proton pump inhibitors?

ABone fractures

BHypomagnesemia

CVitamin B12 deficiency

DClostridium difficile infection

EHelicobacter pylori infection

Suggested Answer: D

Use proton pump inhibitors (PPIs) in patients with or who have risk factors for osteoporosis cautiously. PPIs have been associated with a possible increased risk of bone fractures of the hip, wrist, and spine. Daily treatment with a gastric acid-suppressing medication over a long period of time may lead to hypomagnesemia. Vitamin B12 deficiency has been reported with long term use of PPIs in the literatures. The use of PPIs, may increase the risk of enteric infection by encouraging the growth of gut microflora and increasing susceptibility to organism including Clostridium Difficile. There are recent FDA warnings regarding C. Diff infection with use of PPIs. H. Pylori infection is not a complication of PPIs. PPIs in combination with certain antibiotics are used to treat H. pylori Infections.

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11 comments · newest first

Timothy 11 months ago

Hypomagnesemia is a big one, for sure!

Malinda 12 months ago

I've seen cases of all those complications.

Francesco 12 months ago

Wait, are we sure about E? That seems off.

Willie 12 months ago

I totally agree, those are serious risks!

Beth 1 year ago

A, B, C, and D are all true.

Caitlin 1 year ago

Clostridium difficile infection sounds familiar as a risk, but I’m unsure about Helicobacter pylori. Did we say it was related to PPI use?

Gladys 1 year ago

I feel like vitamin B12 deficiency is definitely a complication, but I can't remember if we covered all the options in detail.

Marcelle 1 year ago

I think hypomagnesemia was mentioned in our lectures, but I can't recall if it was a major concern compared to others like C. diff infections.

Karrie 1 year ago

I remember discussing bone fractures as a potential risk with long-term PPI use, but I'm not entirely sure if it's the only one.

Micaela 1 year ago

Hmm, this question seems straightforward, but I want to make sure I understand the key points about composite sensors before answering.

Brinda 1 year ago

Not sure about this one. I'll need to review the Azure Functions and Cosmos DB documentation to make sure I fully understand how to set up the trigger correctly. Don't want to mess this up.

NABP NAPLEX Exam - Topic 6 Question 19 Discussion