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Which of these medicines is well-known to cause a positive direct Coombs test?
Suggested Answer: A
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The direct Coombs test is used to test for autoimmune hemolyticanemia -- a condition in which the body attacks red blood cells, leading to anemia. Some drugs can cause a positive direct Coombs test -- methyldopa being one of the most well-known (via IgG-mediated type II hypersensitivity reaction). Other drugs that can cause this effect include quinidine (IgM-mediated activation) and penicillins (at very high doses).
12 comments · newest first
PH
Phillip
11 months ago
Hydralazine can also cause issues, but not as commonly!
MA
Martha
11 months ago
Really? I didn't know Methyldopa was that significant.
YU
Yuki
12 months ago
I thought it was Labetalol?
LU
Luisa
12 months ago
Totally agree, it's a classic example.
MA
Margart
12 months ago
Methyldopa is the one that causes a positive Coombs test!
IZ
Izetta
1 year ago
I thought Hydralazine could cause some immune reactions too, but I don't remember it being a classic example like Methyldopa.
GE
Gearldine
1 year ago
I feel like Labetalol might also be related, but I can't recall if it was specifically linked to the Coombs test.
GE
Gerry
1 year ago
I remember practicing a question about drug-induced hemolytic anemia, and Methyldopa was definitely mentioned there.
CA
Carlene
1 year ago
I think Methyldopa is the one that causes a positive direct Coombs test, but I'm not entirely sure.
SA
Salena
1 year ago
The question is asking about a specific security predicate, so I'll need to carefully read the options and understand the differences between them to select the correct one.
XE
Xenia
1 year ago
I've got a good feeling about this one. The question is asking specifically about how the conversion is counted, so I'm guessing it's an EI or EIF. I'll double-check my understanding, but I think I've got this.
MA
Marcos
1 year ago
Hmm, I'm not totally sure how to do this. Do I need to search for Yvonne Mckay's contact first? And then what's the process for forwarding it as a business card?