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NABP NAPLEX Exam - Topic 5 Question 50 Discussion

Which of these medicines is well-known to cause a positive direct Coombs test?
A) Methyldopa
B) Labetalol
C) Hydralazine
D) Nifedipine Section: (none) Explanation

NABP NAPLEX Exam - Topic 5 Question 50 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 50
Topic #: 5
[All NAPLEX Questions]

Which of these medicines is well-known to cause a positive direct Coombs test?

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Suggested Answer: A

The direct Coombs test is used to test for autoimmune hemolyticanemia -- a condition in which the body attacks red blood cells, leading to anemia. Some drugs can cause a positive direct Coombs test -- methyldopa being one of the most well-known (via IgG-mediated type II hypersensitivity reaction). Other drugs that can cause this effect include quinidine (IgM-mediated activation) and penicillins (at very high doses).


by Serina at Jul 31, 2022, 08:27 AM

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Phillip
8 months ago
Hydralazine can also cause issues, but not as commonly!
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Martha
8 months ago
Really? I didn't know Methyldopa was that significant.
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Yuki
9 months ago
I thought it was Labetalol?
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Luisa
9 months ago
Totally agree, it's a classic example.
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Margart
9 months ago
Methyldopa is the one that causes a positive Coombs test!
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Izetta
9 months ago
I thought Hydralazine could cause some immune reactions too, but I don't remember it being a classic example like Methyldopa.
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Gearldine
9 months ago
I feel like Labetalol might also be related, but I can't recall if it was specifically linked to the Coombs test.
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Gerry
9 months ago
I remember practicing a question about drug-induced hemolytic anemia, and Methyldopa was definitely mentioned there.
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Carlene
9 months ago
I think Methyldopa is the one that causes a positive direct Coombs test, but I'm not entirely sure.
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Salena
9 months ago
The question is asking about a specific security predicate, so I'll need to carefully read the options and understand the differences between them to select the correct one.
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Xenia
9 months ago
I've got a good feeling about this one. The question is asking specifically about how the conversion is counted, so I'm guessing it's an EI or EIF. I'll double-check my understanding, but I think I've got this.
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Marcos
10 months ago
Hmm, I'm not totally sure how to do this. Do I need to search for Yvonne Mckay's contact first? And then what's the process for forwarding it as a business card?
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