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NABP NAPLEX Exam - Topic 5 Question 119 Discussion

Which of the following would be most appropriate to treat stenotrophomonas maltophilia?
D) Sulfamethoxazole/trimethoprim
A) Meropenem
B) Vancomycin
C) Ciprofloxacin
E) Cefepime

NABP NAPLEX Exam - Topic 5 Question 119 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 119
Topic #: 5
[All NAPLEX Questions]

Which of the following would be most appropriate to treat stenotrophomonas maltophilia?

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Suggested Answer: D

Primary treatment for stenotrophomonas maltophilia is SMX-TMP. Meropenem, ciprofloxacin, and vancomycin have no coverage.


by Therese at May 04, 2026, 03:54 PM

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Cora
Definitely not vancomycin, that’s for sure!
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Lenny
5 days ago
I thought meropenem was effective too?
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Noah
10 days ago
Sulfamethoxazole/trimethoprim is the go-to for S. maltophilia.
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Jerry
15 days ago
I recall that ciprofloxacin can be used for some resistant infections, but I’m leaning towards sulfamethoxazole/trimethoprim based on what we practiced.
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Margurite
2 months ago
I’m a bit confused about vancomycin. I know it’s for Gram-positive bacteria, but does it have any effect on Stenotrophomonas?
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Jerlene
2 months ago
I feel like sulfamethoxazole/trimethoprim was mentioned in a practice question about this organism. It might be the right choice.
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Amie
2 months ago
I think I remember that Stenotrophomonas maltophilia is often resistant to many antibiotics, but I’m not sure if meropenem is effective.
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