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A 27-year-old female with ovarian cancer is undergoing chemotherapy. She develops subsequent renal failure.
Which of the following drugs is most likely responsible for this?
Suggested Answer: A
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Benign prostatic hyperplasia (BPH) is an example of postrenal acute kidney injury (AKI). Postrenal AKI, as the name suggests, involves an effect 'post' or 'beyond' the kidney, to problems that emerge downstream from the kidney. BPH is one such example of that. Other examples include kidney stones, bladder stones and bladder cancer.
52 comments · newest first
AL
Alyce
11 months ago
Really? I’m surprised it’s not Bleomycin.
LY
Lynelle
11 months ago
Nope, definitely Cisplatin here.
AD
Adela
12 months ago
Wait, I thought it was just Cyclophosphamide that did that?
PA
Paulene
12 months ago
Totally agree, it's a common side effect.
VA
Van
12 months ago
Cisplatin is known for causing renal issues.
VI
Vivan
1 year ago
I'm really unsure about this one. I remember bleomycin being more about lung issues, but I can't recall the others clearly.
TR
Truman
1 year ago
I practiced a question similar to this, and I think it was about cisplatin being linked to renal failure. I hope that's right!
GE
Germaine
1 year ago
I think cyclophosphamide can affect the kidneys too, but I feel like cisplatin is more notorious for that.
TH
Thomasena
1 year ago
I remember reading that cisplatin can cause renal toxicity, but I'm not entirely sure if it's the most common one.
BE
Beckie
1 year ago
Okay, I remember learning about this in class. I think the KStream-GlobalKTable join is the one that doesn't require the same number of partitions.
CH
Chery
1 year ago
Okay, I think I've got this. The key is to create the contract in the right tenant and set the scope appropriately to prevent inter-tenant communication.
CH
Cherilyn
1 year ago
Okay, I remember learning about these types of plans in class. I think the key is to focus on the immediate recovery of operations after a disaster.
KI
Kiley
1 year ago
This seems like a straightforward question. I'll go with PolarDB MySQL since it's the closest to the database I'm currently using.
LE
Lelia
1 year ago
Wow, Cisplatin is really putting the 'fail' in 'renal failure'! Gotta be careful with that one.
DU
Dustin
1 year ago
D: Hopefully they can manage the renal failure and continue with the treatment.
DA
Dana
1 year ago
C: Definitely important to monitor kidney function closely during treatment.
WA
Wai
1 year ago
B: I heard it's a common side effect of chemotherapy drugs.
MA
Matt
1 year ago
A: Yeah, Cisplatin can be pretty harsh on the kidneys.
IS
Isabelle
1 year ago
Hmm, Cisplatin sounds like the culprit. Kidneys and chemo, not a good combo. Maybe we should start a support group for overworked oncology kidneys.
LE
Lezlie
1 year ago
We should definitely raise awareness about the potential side effects of chemotherapy drugs.
MA
Marg
1 year ago
Yeah, it's a tough situation for the kidneys to handle.
AR
Ariel
1 year ago
Cisplatin is definitely known for causing renal failure.
GR
Grover
1 year ago
Cisplatin, no doubt. It's like a double-edged sword - kills the cancer but can also take down the kidneys. Tricky stuff!
HU
Hubert
1 year ago
E) Vincristine
LO
Lon
1 year ago
D) Vinblastine
CA
Caprice
1 year ago
C) Cisplatin
TI
Tijuana
1 year ago
B) Bleomycin
OC
Octavio
1 year ago
A) Cyclophosphamide
AD
Adelle
1 year ago
My money's on Cisplatin too. Gotta watch out for those kidneys when using the heavy hitters.
LA
Laquita
1 year ago
Always important to monitor kidney function during chemotherapy.
SO
Sol
1 year ago
Yep, gotta be careful with those nephrotoxic drugs during chemo.
NO
Novella
1 year ago
Agreed, Cisplatin is a nephrotoxic drug.
PE
Pete
1 year ago
Definitely Cisplatin. It's known for causing renal failure.
AU
Audra
1 year ago
E) Vincristine
AD
Adela
1 year ago
D) Vinblastine
AS
Asha
1 year ago
C) Cisplatin
JO
Josephine
1 year ago
B) Bleomycin
ME
Meaghan
1 year ago
A) Cyclophosphamide
SA
Sarina
1 year ago
Yep, Cisplatin is a common culprit for renal failure in cancer patients.
LU
Luisa
1 year ago
Agreed, Cisplatin is notorious for its nephrotoxicity.
GL
Glendora
1 year ago
Definitely Cisplatin. It's known to cause renal failure.
MA
Marnie
1 year ago
E) Vincristine
BR
Brynn
1 year ago
D) Vinblastine
KA
Kati
1 year ago
C) Cisplatin
TE
Terrilyn
1 year ago
B) Bleomycin
JA
Jarvis
1 year ago
A) Cyclophosphamide
MA
Marsha
1 year ago
I'm not sure, but I think it could be A) Cyclophosphamide as well.
TA
Tayna
1 year ago
I agree with Nobuko. Cisplatin is known to cause renal failure.
AL
Alberto
1 year ago
Cisplatin is the obvious choice here. Renal toxicity is a well-known side effect of this chemotherapy drug.
HU
Hubert
1 year ago
Yeah, I agree. Cisplatin is notorious for its nephrotoxicity.
AN
Angelica
1 year ago
Cisplatin is definitely the culprit here. It's known for causing renal failure.
NO
Nobuko
2 years ago
I think the answer is C) Cisplatin.