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Diabetic ketoacidosis, a potential complication of type 2 diabetes, is most associated which of the following antidiabetic drug classes?
Suggested Answer: B
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SGLT-2 inhibitors have a black box warning for diabetic ketoacidosis, which manifests as euglycemic and makes it relatively difficult to detect without monitoring. The complex physiology by which this occurs is not clearly understood. On the other end, they have been shown to reduce major cardiovascular events (MACE) in persons with type 2 diabetes and established cardiovascular disease.
11 comments · newest first
RO
Rosendo
11 months ago
Biguanides don’t cause DKA, right?
MI
Mirta
12 months ago
Wait, are we sure about that?
CA
Carman
12 months ago
Totally agree, SGLT-2s are the ones!
RE
Ressie
12 months ago
I thought it was sulfonylureas?
JU
Justine
1 year ago
DKA is mainly linked to SGLT-2 inhibitors.
CA
Carmela
1 year ago
I feel like biguanides, like metformin, are generally safe, but I need to double-check if they have any connection to DKA.
ME
Merissa
1 year ago
I think sulfonylureas were mentioned in a practice question, but I can't recall if they were linked to DKA specifically.
RO
Rosalind
1 year ago
I remember studying that DKA is more common with SGLT-2 inhibitors, but I'm not entirely sure if that's the only class associated with it.
TA
Tamekia
1 year ago
I vaguely remember something about thiazolidinediones and their risks, but I can't remember if they were directly related to DKA.
AB
Abraham
1 year ago
Hmm, I'm a bit confused on the differences between the phases. I'll need to review my notes to make sure I understand them properly.
NO
Noah
1 year ago
I've got this! The question is asking us to set the firming time fence, and since we need to firm the planned orders within the current month, the answer is clearly option D - set the firming time fence to one month.