NABP NAPLEX Exam - Topic 4 Question 6 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 6
Topic #: 4

Diabetic ketoacidosis, a potential complication of type 2 diabetes, is most associated which of the following antidiabetic drug classes?

ADPP-4 inhibitors

BSGLT-2 inhibitors

CSulfonylureas

DBiguanides

EThiazolidinediones

Show Suggested Answer

Suggested Answer: B

SGLT-2 inhibitors have a black box warning for diabetic ketoacidosis, which manifests as euglycemic and makes it relatively difficult to detect without monitoring. The complex physiology by which this occurs is not clearly understood. On the other end, they have been shown to reduce major cardiovascular events (MACE) in persons with type 2 diabetes and established cardiovascular disease.

by Lezlie at May 03, 2022, 01:40 PM

Limited Time Offer

25%

Off

Get Premium NAPLEX Questions as Interactive Web-Based Practice Test or PDF

Contribute your Thoughts:

Submit Cancel

Rosendo

4 months ago

Biguanides don’t cause DKA, right?

upvoted 0 times

...

Mirta

4 months ago

Wait, are we sure about that?

upvoted 0 times

...

Carman

4 months ago

Totally agree, SGLT-2s are the ones!

upvoted 0 times

...

Ressie

4 months ago

I thought it was sulfonylureas?

upvoted 0 times

...

Justine

5 months ago

DKA is mainly linked to SGLT-2 inhibitors.

upvoted 0 times

...

Carmela

5 months ago

I feel like biguanides, like metformin, are generally safe, but I need to double-check if they have any connection to DKA.

upvoted 0 times

...

Merissa

5 months ago

I think sulfonylureas were mentioned in a practice question, but I can't recall if they were linked to DKA specifically.

upvoted 0 times

...

Rosalind

5 months ago

I remember studying that DKA is more common with SGLT-2 inhibitors, but I'm not entirely sure if that's the only class associated with it.

upvoted 0 times

...

Tamekia

5 months ago

I vaguely remember something about thiazolidinediones and their risks, but I can't remember if they were directly related to DKA.

upvoted 0 times

...

Abraham

5 months ago

Hmm, I'm a bit confused on the differences between the phases. I'll need to review my notes to make sure I understand them properly.

upvoted 0 times

...

Noah

5 months ago

I've got this! The question is asking us to set the firming time fence, and since we need to firm the planned orders within the current month, the answer is clearly option D - set the firming time fence to one month.

upvoted 0 times

...