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NABP Exam NAPLEX Topic 2 Question 67 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 67
Topic #: 2
[All NAPLEX Questions]

Your patient is a 58-year-old male who presents with onset of severe substernal chest pain and shortness of breath. An ECG reveals an acute STEMI, and he is on his way to the cardiac catheterization suite for percutaneous coronary intervention.

Which of the following drugs used in acute coronary syndromes treated with PCI must undergo oxidation by hepatic P450 enzymes to an active form?

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Suggested Answer: A

Benign prostatic hyperplasia (BPH) is an example of postrenal acute kidney injury (AKI). Postrenal AKI, as the name suggests, involves an effect 'post' or 'beyond' the kidney, to problems that emerge downstream from the kidney. BPH is one such example of that. Other examples include kidney stones, bladder stones and bladder cancer.


Contribute your Thoughts:

Beth
3 days ago
Ugh, I always get these P450 enzyme activation questions mixed up. Time to brush up on my acute coronary syndrome pharmacology.
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Lovetta
10 days ago
I remember learning about the importance of clopidogrel's activation in pharmacology. Looks like I'm ready for this question!
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Rasheeda
12 days ago
I'm not sure, but I think it's C) Eptifibatide.
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Luther
12 days ago
Clopidogrel is the correct answer. It's a prodrug that requires metabolic activation by hepatic P450 enzymes to become its active form.
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Noel
17 days ago
I agree with Geoffrey, Clopidogrel needs hepatic P450 enzymes for activation.
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Geoffrey
23 days ago
I think the answer is A) Clopidogrel.
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