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NABP NAPLEX Exam - Topic 2 Question 111 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 111
Topic #: 2
[All NAPLEX Questions]

Which of the following antidiabetic medication may cause cyanocobalamin deficiency?

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Suggested Answer: E

Metformin is associated with vitamin B12 deficiency because it affects the calcium dependent membrane uptake of it. All other drug classes are not associated with this.


by Reyes at Nov 21, 2025, 03:36 PM

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Delmy
10 hours ago
Surprised to learn Metformin has that side effect!
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Vicky
6 days ago
Canagliflozin doesn't do that, right?
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Cletus
11 days ago
Really? I thought it was just a myth.
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Junita
16 days ago
Metformin is the one that can cause cyanocobalamin deficiency.
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Hyun
21 days ago
I'm feeling lucky, I'll go with C. Pioglitazone. Sounds like it could be a wild card.
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Gilberto
26 days ago
E. Metformin, no doubt. That stuff is like a vitamin-sucking vampire.
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Shalon
1 month ago
Haha, I bet the answer is D. Glimepiride, just to trick us all!
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Paris
1 month ago
I'm going with B. Canagliflozin, it just sounds like it could mess with your vitamins.
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Clay
1 month ago
I practiced a similar question last week, and it was definitely about Metformin causing B12 deficiency. I hope that helps!
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Kasandra
2 months ago
I’m not confident, but I feel like it could be one of the other options too. Did we cover any other medications that affect vitamin levels?
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Laticia
2 months ago
I remember something about Metformin and vitamin B12 deficiency from my notes. It seems to fit this question.
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Salome
2 months ago
Wait, I'm a bit confused. I thought pioglitazone was the one that could lead to B12 deficiency. Let me review my notes again.
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Kristeen
2 months ago
I'm pretty confident it's E) Metformin. That's the one I remember learning about causing cyanocobalamin issues.
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Cristal
2 months ago
I think Metformin is the one that can cause cyanocobalamin deficiency, but I'm not entirely sure.
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Lizbeth
2 months ago
Hmm, I think it's E. Metformin, that one always seems to cause issues.
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Michell
3 months ago
I've got a strategy - I'll eliminate the ones I'm sure don't cause B12 deficiency, then focus on the remaining options. Gotta use the process of elimination here.
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Bulah
3 months ago
Totally agree, I've read that too!
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Galen
3 months ago
Okay, I know metformin can cause B12 deficiency, so that's my best guess. But I'm not totally sure about the others.
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Enola
3 months ago
Hmm, this is a tricky one. I'll need to think carefully about the mechanisms of action for each of these medications.
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