NABP NAPLEX Exam - Topic 2 Question 109 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 109
Topic #: 2

[All NAPLEX Questions]

Which of the following class of antidiabetic medication may cause fluid retention?

ABile acid sequestrant

BGLP-1 agonist

CThiazolidinediones

DSGLT2 Inhibitor

EAlpha-glucosidase inhibitor

Show Suggested Answer

Suggested Answer: C

Thiazolidinediones may cause fluid retention through proposed mechanism of increasing reabsorption in the collecting duct of the kidney and increasing vascular permeability in adipose tissue. Bile acid sequestrants work in the intestine to bind bile acids which doesn't affect fluid retention. GLP-1 receptor agonists work to activate these receptors to secrete insulin from beta pancreatic cells/decrease glucagon secretion/ increase satiety and doesn't affect fluid retention. SGLT2 inhibitors actually cause increase of fluid elimination through the kidneys. Alpha-glucosidase inhibitors work in the gut to decrease carb absorption/digestion and have no affect on fluid retention.

by Mitsue at Aug 03, 2025, 12:18 AM

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Jacquline

7 months ago

Bile acid sequestrants don't cause fluid retention, right?

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Antione

7 months ago

Wait, really? I thought SGLT2 inhibitors were the ones to watch for that.

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Jackie

7 months ago

Totally agree, I've seen that in my patients.

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Haydee

7 months ago

Yup, it's definitely the thiazolidinediones!

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Tamesha

8 months ago

Thiazolidinediones can cause fluid retention.

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Denna

8 months ago

I’m confused about SGLT2 inhibitors; I thought they were more about getting rid of glucose and not retaining fluid.

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Gracia

8 months ago

I feel like bile acid sequestrants might have some side effects, but fluid retention doesn't sound right for them.

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Kaitlyn

8 months ago

I remember practicing a question about GLP-1 agonists, but I don't think they cause fluid retention like thiazolidinediones do.

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Scarlet

9 months ago

I think thiazolidinediones are the ones that can cause fluid retention, but I'm not entirely sure.

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Janey

9 months ago

I'm pretty confident the answer is C. Thiazolidinediones are the class of antidiabetic drugs that can lead to fluid retention, often resulting in edema. This is an important adverse effect to be aware of when prescribing these medications.

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Colton

9 months ago

Okay, I think I've got this. Thiazolidinediones, like pioglitazone, are known to cause fluid retention as a common side effect. That's the class I'll select for this question.

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Barrie

9 months ago

Hmm, I'm a bit unsure about this one. I know some of the classes can cause fluid retention, but I'm not sure which one specifically. I'll need to review my notes on the side effect profiles of these medications.

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Lottie

9 months ago

This is a good question to test our knowledge of the different classes of antidiabetic medications and their side effects. I'll need to think through the mechanisms of action and potential adverse effects for each option.

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