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Which of the following class of antidiabetic medication may cause fluid retention?
Suggested Answer: C
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Thiazolidinediones may cause fluid retention through proposed mechanism of increasing reabsorption in the collecting duct of the kidney and increasing vascular permeability in adipose tissue. Bile acid sequestrants work in the intestine to bind bile acids which doesn't affect fluid retention. GLP-1 receptor agonists work to activate these receptors to secrete insulin from beta pancreatic cells/decrease glucagon secretion/ increase satiety and doesn't affect fluid retention. SGLT2 inhibitors actually cause increase of fluid elimination through the kidneys. Alpha-glucosidase inhibitors work in the gut to decrease carb absorption/digestion and have no affect on fluid retention.
23 comments · newest first
JA
Jacquline
10 months ago
Bile acid sequestrants don't cause fluid retention, right?
AN
Antione
10 months ago
Wait, really? I thought SGLT2 inhibitors were the ones to watch for that.
JA
Jackie
10 months ago
Totally agree, I've seen that in my patients.
HA
Haydee
10 months ago
Yup, it's definitely the thiazolidinediones!
TA
Tamesha
11 months ago
Thiazolidinediones can cause fluid retention.
DE
Denna
11 months ago
I’m confused about SGLT2 inhibitors; I thought they were more about getting rid of glucose and not retaining fluid.
GR
Gracia
11 months ago
I feel like bile acid sequestrants might have some side effects, but fluid retention doesn't sound right for them.
KA
Kaitlyn
11 months ago
I remember practicing a question about GLP-1 agonists, but I don't think they cause fluid retention like thiazolidinediones do.
SC
Scarlet
12 months ago
I think thiazolidinediones are the ones that can cause fluid retention, but I'm not entirely sure.
JA
Janey
12 months ago
I'm pretty confident the answer is C. Thiazolidinediones are the class of antidiabetic drugs that can lead to fluid retention, often resulting in edema. This is an important adverse effect to be aware of when prescribing these medications.
CO
Colton
12 months ago
Okay, I think I've got this. Thiazolidinediones, like pioglitazone, are known to cause fluid retention as a common side effect. That's the class I'll select for this question.
BA
Barrie
1 year ago
Hmm, I'm a bit unsure about this one. I know some of the classes can cause fluid retention, but I'm not sure which one specifically. I'll need to review my notes on the side effect profiles of these medications.
LO
Lottie
1 year ago
This is a good question to test our knowledge of the different classes of antidiabetic medications and their side effects. I'll need to think through the mechanisms of action and potential adverse effects for each option.
LI
Lili
1 year ago
I agree with Junita, Thiazolidinediones can cause fluid retention.
JU
Junita
1 year ago
I think the answer is C) Thiazolidinediones.
SH
Shantay
1 year ago
Hmm, let me think. I'm gonna go with C) Thiazolidinediones. Isn't that the class that makes you swell up like a balloon?
AL
Alonzo
1 year ago
User 2: I think it's D) SGLT2 Inhibitor. They can also lead to fluid retention.
CL
Clay
1 year ago
User 1: Yeah, you're right. Thiazolidinediones can definitely cause fluid retention.
AS
Ashlyn
1 year ago
Ah, I remember learning about this in class. It's gotta be C) Thiazolidinediones. They really pack on the pounds, don't they?
MI
Milly
1 year ago
C) Thiazolidinediones, for sure. Fluid retention is a well-known side effect of this class of medications.
LI
Lili
1 year ago
A) Bile acid sequestrant does not typically cause fluid retention.
JE
Jeanice
1 year ago
D) SGLT2 Inhibitor can also cause fluid retention.
LI
Lizbeth
1 year ago
C) Thiazolidinediones, for sure. Fluid retention is a well-known side effect of this class of medications.