NABP NAPLEX Exam - Topic 2 Question 104 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 104
Topic #: 2

[All NAPLEX Questions]

Select the class of Anti-diabetic medication that works in the specified organ to prevent hyperglycemi

a. Select all that applies. Liver (D)

ASulfonylureas

BAlpha- Glucosidase Inhibitors

CDPP4 Inhibitors

DGlucagon-like peptide-1 receptor agonists

EThiazolidinediones

FBiguanide

GSGLT2 inhibitors

Show Suggested Answer

Suggested Answer: C

DPP4 Inhibitors, (D)Glucagon-like peptide-1 receptor agonists, (E)Thiazolidinediones (F)Biguanide Sulfonylureas work in beta cells in the pancreas that are still functioning to enhance insulin secretion. Alpha- Glucosidase Inhibitors stop -glucosidase enzymes in the small intestine and delay digestion and absorption of starch and disaccharides which lowers the levels of glucose after meals. DPP4 blocks the degradation ofGLP-1, GIP, and a variety of other peptides, including brain natriuretic peptide. Glucagon-like peptide-1 receptor agonists work in various organs of the body. Glucagon-like peptide-1 receptor agonists enhance glucose homeostasis through: (i) stimulation of insulin secretion; (ii) inhibition of glucagon secretion; (iii) direct and indirect suppression of endogenous glucose production; (iv) suppression of appetite; (v) enhanced insulin sensitivity secondary to weight loss; (vi) delayed gastric emptying, resulting in decreased postprandial hyperglycaemia. Thiazolidinediones are the only true insulin-sensitising agents, exerting their effects in skeletal and cardiac muscle, liver, and adipose tissue. It ameliorates insulin resistance, decreases visceral fat.

Biguanides work in liver, muscle, adipose tissue via activation of AMP-activated protein kinase (AMPK) reduce hepatic glucose production. SGLT2 inhibitors work in the kidneys to inhibit sodium-glucose transport proteins to reabsorb glucose into the blood from muscle cells; overall this helps to improve insulin release from the beta cells of the pancreas.

https://doi.org/10.1093/eurheartj/ehv239

by France at Apr 05, 2025, 06:43 AM

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Rosendo

5 months ago

Wait, are you sure about that? I thought it was just for insulin sensitivity.

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Mertie

5 months ago

Totally agree, they help reduce glucose production.

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Mickie

5 months ago

Biguanides work in the liver!

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Verdell

6 months ago

Yup, DPP4 inhibitors are more about the gut!

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Jacob

6 months ago

Sulfonylureas don’t target the liver, right?

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Glendora

6 months ago

I feel like DPP4 inhibitors and GLP-1 agonists are more about increasing insulin secretion and slowing gastric emptying, not directly on the liver.

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Olene

6 months ago

I practiced a similar question, and I think thiazolidinediones also have some effect on the liver, but I’m not confident about that.

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Fernanda

7 months ago

I’m not entirely sure about the others, but I think sulfonylureas mainly stimulate insulin release from the pancreas, right?

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Kara

7 months ago

I remember that biguanides, like metformin, primarily act on the liver to reduce glucose production.

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Matthew

7 months ago

I'm a little confused on this one. I know the liver is important for glucose homeostasis, but I'm not sure which specific drug classes work there. I'll have to think it through carefully.

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Crista

7 months ago

I've got this! Sulfonylureas, biguanides, and GLP-1 agonists all have effects in the liver. I'll select those.

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Carin

7 months ago

Okay, let's see. The liver is involved in glucose regulation, so I'll need to identify which meds target the liver to control blood sugar levels.

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Kindra

8 months ago

Hmm, I'm a bit unsure about this one. I'll need to think through the mechanism of action for each class of anti-diabetic drugs.

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Karan

8 months ago

This question looks straightforward, I just need to remember which anti-diabetic meds work in the liver to prevent hyperglycemia.

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Cristal

1 year ago

Aha! D is the correct answer. I'm feeling like a med school pro right now. (Flexes imaginary muscles)

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Douglass

1 year ago

D is the way to go, for sure. The other options might work, but Glucagon-like peptide-1 receptor agonists are the real MVP when it comes to liver-specific anti-diabetic action. (Winks)

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Maurine

11 months ago

SGLT2 inhibitors are also known to have some impact on the liver in preventing hyperglycemia.

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Marti

11 months ago

I prefer Thiazolidinediones for liver-specific anti-diabetic action.

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Eric

11 months ago

I think Sulfonylureas and DPP4 Inhibitors also work in the liver to prevent hyperglycemia.

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Claudia

12 months ago

I agree, Glucagon-like peptide-1 receptor agonists are really effective for liver-specific action.

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Jackie

1 year ago

Hmm, I'm not sure about this one. I think I'll go with A, B, and C. They all sound like they could work, right? (Laughs) Gotta cover all my bases!

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Rutha

11 months ago

Sarah: Yeah, you're right. D and G are the correct choices for medications that work in the liver.

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Sarah

11 months ago

User 2: I think D and G are the ones that work in the liver to prevent hyperglycemia.

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Wilda

12 months ago

User 1: Actually, A, B, and C don't work in the liver. You might want to reconsider your choices.

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Dulce

1 year ago

I agree with Anastacia. Glucagon-like peptide-1 receptor agonists are the only option that specifically targets the liver to control blood sugar levels.

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