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NABP NAPLEX Exam - Topic 10 Question 81 Discussion

Which of the following is true regarding extent of absorption of drugs?
A) After oral ingestion of drugs, the absorption of drug may be incomplete
B) Drugs which are too lipophilic cannot cross the lipid cell membrane
C) Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell
D) P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug
E) Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs

NABP NAPLEX Exam - Topic 10 Question 81 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 81
Topic #: 10
[All NAPLEX Questions]

Which of the following is true regarding extent of absorption of drugs?

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Suggested Answer: A

The dihydropyridine drug -- nifedipine -- is the active ingredient found in the medicine Adalat. Nifedipine is used to treat angina, Reynaud's phenomenon and hypertension. It is also used as a tocolytic agent in premature labor.


by Yoko at May 09, 2024, 07:01 AM

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Celia
8 months ago
B is misleading, lipophilic drugs can cross membranes, just slower.
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Brittni
9 months ago
Wait, grape juice affects drug absorption? That's surprising!
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Elbert
9 months ago
C makes sense, hydrophilic drugs struggle with that water layer.
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Paola
9 months ago
I disagree with D, P-glycoprotein actually reduces absorption.
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Tracey
9 months ago
A is definitely true, absorption can be incomplete.
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Kenneth
10 months ago
I vaguely remember something about P-glycoprotein, but I thought it was more about limiting absorption rather than enhancing it. So, I’m unsure about option D.
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Verdell
10 months ago
I practiced a question similar to this, and I recall that hydrophilic drugs struggle with crossing membranes due to their solubility issues. So, option C seems plausible.
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Alfred
10 months ago
I'm not entirely sure, but I think lipophilic drugs can actually cross cell membranes. Isn't that why they are often more bioavailable?
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Natalie
10 months ago
I remember that oral drug absorption can be incomplete, especially with certain formulations. So, I think option A might be true.
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Stephen
10 months ago
Alright, let me review what I know about lipophilicity, hydrophilicity, and transporters like P-glycoprotein. I think I can narrow this down.
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Tomoko
10 months ago
Okay, I know the basics of drug absorption, so I should be able to figure this out.
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Cassi
10 months ago
Hmm, I'm a bit unsure about the details of drug absorption. Let me think this through carefully.
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Scarlet
10 months ago
This question seems straightforward, I think I can handle it.
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Emily
10 months ago
Ugh, I'm not too confident in my pharmacology knowledge. This is going to be tricky.
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Denny
10 months ago
The Form-Based Composer seems like it could work, but I'm not confident that it would provide the level of control and customization needed for this type of test.
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Alesia
10 months ago
I think the answer is True, but I'm a bit uncertain. I'll make a note to research this topic more before the exam to solidify my understanding.
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Nan
11 months ago
Okay, let me think this through. The question is asking about the first program the Linux kernel starts at boot time using System V init. That means it's likely going to be one of the standard init-related paths, not something more obscure. I'm going to go with /sbin/init as my best guess.
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Adell
1 year ago
Option E is just plain funny. Grape juice as a drug absorption inhibitor? Maybe they should add wine as a choice too, for a more 'spirited' exam experience.
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Whitley
1 year ago
C) Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell
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Keneth
1 year ago
B) Drugs which are too lipophilic cannot cross the lipid cell membrane
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Brandon
1 year ago
A) After oral ingestion of drugs, the absorption of drug may be incomplete
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Haydee
1 year ago
D is incorrect. P-glycoprotein is an efflux transporter that actually reduces drug absorption, not enhances it. Grape juice inhibiting P-glycoprotein could potentially increase drug absorption, not decrease it.
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William
1 year ago
I'm not sure about B and C. Shouldn't the drug's physicochemical properties be balanced to achieve optimal absorption? Maybe I need to review my lipophilicity and hydrophilicity concepts.
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Willie
1 year ago
User 4: D) P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug
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Ciara
1 year ago
User 3: I'm not sure about B and C. Shouldn't the drug's physicochemical properties be balanced to achieve optimal absorption? Maybe I need to review my lipophilicity and hydrophilicity concepts.
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Dortha
1 year ago
User 2: E) Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs
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Royce
1 year ago
User 1: A) After oral ingestion of drugs, the absorption of drug may be incomplete
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Lourdes
1 year ago
I agree with A. Incomplete absorption is a common phenomenon, and it's crucial to understand the factors affecting it, like you mentioned.
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Kent
1 year ago
User 2: Yeah, it's important to consider factors affecting absorption.
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Asuncion
1 year ago
User 1: I think A is true, incomplete absorption happens often.
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Zoila
1 year ago
Option A is correct. Drug absorption can indeed be incomplete after oral administration due to various factors like first-pass metabolism, drug efflux transporters, and physicochemical properties of the drug.
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Murray
1 year ago
That's a good point, but I still think A is more likely based on what I've studied.
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Gail
1 year ago
I disagree, I believe B is true because lipophilic drugs have difficulty crossing cell membranes.
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Murray
1 year ago
I think A is true because some drugs are not fully absorbed after oral ingestion.
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