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NABP Exam NAPLEX Topic 10 Question 81 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 81
Topic #: 10
[All NAPLEX Questions]

Which of the following is true regarding extent of absorption of drugs?

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Suggested Answer: A

The dihydropyridine drug -- nifedipine -- is the active ingredient found in the medicine Adalat. Nifedipine is used to treat angina, Reynaud's phenomenon and hypertension. It is also used as a tocolytic agent in premature labor.


by Yoko at May 09, 2024, 07:01 AM

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Adell
2 months ago
Option E is just plain funny. Grape juice as a drug absorption inhibitor? Maybe they should add wine as a choice too, for a more 'spirited' exam experience.
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Whitley
18 days ago
C) Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell
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Keneth
20 days ago
B) Drugs which are too lipophilic cannot cross the lipid cell membrane
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Brandon
2 months ago
A) After oral ingestion of drugs, the absorption of drug may be incomplete
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Haydee
2 months ago
D is incorrect. P-glycoprotein is an efflux transporter that actually reduces drug absorption, not enhances it. Grape juice inhibiting P-glycoprotein could potentially increase drug absorption, not decrease it.
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William
2 months ago
I'm not sure about B and C. Shouldn't the drug's physicochemical properties be balanced to achieve optimal absorption? Maybe I need to review my lipophilicity and hydrophilicity concepts.
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Willie
14 days ago
User 4: D) P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug
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Ciara
1 months ago
User 3: I'm not sure about B and C. Shouldn't the drug's physicochemical properties be balanced to achieve optimal absorption? Maybe I need to review my lipophilicity and hydrophilicity concepts.
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Dortha
1 months ago
User 2: E) Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs
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Royce
2 months ago
User 1: A) After oral ingestion of drugs, the absorption of drug may be incomplete
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Lourdes
3 months ago
I agree with A. Incomplete absorption is a common phenomenon, and it's crucial to understand the factors affecting it, like you mentioned.
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Kent
2 months ago
User 2: Yeah, it's important to consider factors affecting absorption.
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Asuncion
2 months ago
User 1: I think A is true, incomplete absorption happens often.
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Zoila
3 months ago
Option A is correct. Drug absorption can indeed be incomplete after oral administration due to various factors like first-pass metabolism, drug efflux transporters, and physicochemical properties of the drug.
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Murray
3 months ago
That's a good point, but I still think A is more likely based on what I've studied.
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Gail
3 months ago
I disagree, I believe B is true because lipophilic drugs have difficulty crossing cell membranes.
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Murray
3 months ago
I think A is true because some drugs are not fully absorbed after oral ingestion.
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