Discuss NABP NAPLEX Exam Topic 10 Question 42

In the US Nurses' Health Study (NHS) cohort study, where they looked at association of regular aspirin use (two 325 mg tablets/week) and colorectal cancer in 82,911 women found (RR, 0.77; 95% CI, 0.67--0.88) over 20 years of follow-up.

In an another analysis of the NHS, regular aspirin use, investigator also found (hazard ratio [HR]=0.72, 95% CI 0.56--0.92), what does this say about the mortality from colorectal cancer? How can this data best be interpreted?

AThose who takes aspirin 2 times/week have 23% lower risk of colorectal cancer

BThose who takes aspirin 2 times/week have 0.77% lower risk of colorectal cancer

CThose who takes aspirin 2 times/week have 28% lower risk of colorectal cancer

DThose who takes aspirin 2 times/week have 23% reduction in death from colorectal cancer

ENone of the above is correct

Suggested Answer: A

Relative risk can be stated as 0.77 times as likely or 0.77 times the risk, but it could also be illustrated as a relative risk reduction and stated as a 23% risk reduction or 23% lower risk by taking the medication.

https://www.ncbi.nlm.nih.gov/books/NBK63647/

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13 comments · newest first

Virgie 11 months ago

I thought aspirin was just for headaches, this is surprising!

Crista 12 months ago

The hazard ratio suggests a 28% lower risk, not 23%.

Stanford 12 months ago

Wait, how can we be sure this is causal?

Eun 12 months ago

Totally agree, the data shows a solid reduction!

Myra 1 year ago

Those who take aspirin 2 times/week have 23% lower risk of colorectal cancer.

Johnathon 1 year ago

I feel like none of the options fully capture the data, so maybe E is the best answer after all.

Noel 1 year ago

I practiced a similar question, and I think the 28% reduction in option C sounds familiar, but I can't recall the exact details.

Coral 1 year ago

I'm not entirely sure, but I thought hazard ratios were more about mortality, so maybe D is the right choice?

Joanne 1 year ago

I remember that relative risk of 0.77 means a 23% reduction, so I think option A could be correct.

Lillian 1 year ago

Hmm, this seems straightforward. I think filtering the data based on a specific date range is the way to go.

Royal 1 year ago

Hmm, I'm a little unsure about this one. I know we need to limit visibility, but I'm not sure if disabling hierarchies or setting the org-wide default to private is the right approach.

Ciara 1 year ago

Okay, let me walk through this step-by-step. The question is asking for the command to update an already installed RPM package. I believe the correct answer is A, "rpm --update rpmname". That makes the most sense to me based on my understanding of RPM package management.

Clarence 1 year ago

I'm pretty sure the answer is SSL. That's the standard for securing web traffic, right?

NABP NAPLEX Exam - Topic 10 Question 42 Discussion