NABP NAPLEX Exam - Topic 10 Question 18 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 18
Topic #: 10

Concomitant use of warfarin and omeprazole is associated with increased INR and prothrombin time(PT). What enzyme dose the omeprazole inhibits that is metabolized by warfarin?

ACYP3A4

BCYP2C9

CCYP2C19

DCYP2D9

ECYP1A2

Show Suggested Answer

Suggested Answer: C

Omeprazole is CYP2C19 inhibitor which can prolong the elimination of warfarin, particularly R-warfarin. R- warfarin is partially metabolized by CYP2C19. The combined use of omeprazole and warfarin has been associated with reports of increased INR and prothrombin time (PT).

by Keneth at May 05, 2022, 01:49 PM

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Jerry

4 months ago

Interesting, I didn't know omeprazole had that effect!

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Rory

4 months ago

Yup, CYP2C19 affects warfarin metabolism for sure.

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Selma

4 months ago

Wait, are we sure about that? I thought it was CYP2C9.

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Talia

4 months ago

Totally agree, CYP2C19 is the one!

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Chauncey

5 months ago

Omeprazole inhibits CYP2C19, right?

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Georgeanna

5 months ago

I’m a bit confused about the CYP enzymes. I thought warfarin was mostly metabolized by CYP2C9, but does omeprazole inhibit that too?

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Mabelle

5 months ago

I think omeprazole mainly inhibits CYP2C19, which could affect warfarin metabolism. I saw a similar question in our practice exam.

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Lucy

5 months ago

I remember that omeprazole is a proton pump inhibitor, but I'm not entirely sure which CYP enzyme it affects.

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German

5 months ago

I recall that CYP2C19 is the one that omeprazole inhibits, but I hope I’m not mixing it up with CYP2C9.

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Chau

5 months ago

I'm pretty confident the answer is C. The link doesn't use SSL/TLS encryption, so Marcella shouldn't proceed with the transaction.

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Micah

5 months ago

I'm a little confused on this one. Is it really just list hygiene, or could it be something like engagement that's impacting deliverability? I'll have to review the material again to make sure I understand the connection to spam traps.

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