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Concomitant use of warfarin and omeprazole is associated with increased INR and prothrombin time(PT). What enzyme dose the omeprazole inhibits that is metabolized by warfarin?
Suggested Answer: C
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Omeprazole is CYP2C19 inhibitor which can prolong the elimination of warfarin, particularly R-warfarin. R- warfarin is partially metabolized by CYP2C19. The combined use of omeprazole and warfarin has been associated with reports of increased INR and prothrombin time (PT).
11 comments · newest first
JE
Jerry
11 months ago
Interesting, I didn't know omeprazole had that effect!
RO
Rory
12 months ago
Yup, CYP2C19 affects warfarin metabolism for sure.
SE
Selma
12 months ago
Wait, are we sure about that? I thought it was CYP2C9.
TA
Talia
12 months ago
Totally agree, CYP2C19 is the one!
CH
Chauncey
1 year ago
Omeprazole inhibits CYP2C19, right?
GE
Georgeanna
1 year ago
I’m a bit confused about the CYP enzymes. I thought warfarin was mostly metabolized by CYP2C9, but does omeprazole inhibit that too?
MA
Mabelle
1 year ago
I think omeprazole mainly inhibits CYP2C19, which could affect warfarin metabolism. I saw a similar question in our practice exam.
LU
Lucy
1 year ago
I remember that omeprazole is a proton pump inhibitor, but I'm not entirely sure which CYP enzyme it affects.
GE
German
1 year ago
I recall that CYP2C19 is the one that omeprazole inhibits, but I hope I’m not mixing it up with CYP2C9.
CH
Chau
1 year ago
I'm pretty confident the answer is C. The link doesn't use SSL/TLS encryption, so Marcella shouldn't proceed with the transaction.
MI
Micah
1 year ago
I'm a little confused on this one. Is it really just list hygiene, or could it be something like engagement that's impacting deliverability? I'll have to review the material again to make sure I understand the connection to spam traps.