NABP NAPLEX Exam - Topic 2 Question 111 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 111
Topic #: 2

[All NAPLEX Questions]

Which of the following antidiabetic medication may cause cyanocobalamin deficiency?

ASaxagliptin

BCanagliflozin

CPioglitazone

DGlimepiride

EMetformin

Show Suggested Answer

Suggested Answer: E

Metformin is associated with vitamin B12 deficiency because it affects the calcium dependent membrane uptake of it. All other drug classes are not associated with this.

by Reyes at Nov 21, 2025, 03:36 PM

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Fletcher

3 months ago

Good point! It's crucial to monitor B12 levels with it.

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Basilia

3 months ago

Metformin is the main one linked to cyanocobalamin issues.

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Walton

3 months ago

I agree, but I feel unsure about the others.

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Barney

4 months ago

Definitely Metformin. It's common knowledge.

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Isadora

4 months ago

Yeah, I've heard it can cause B12 deficiency.

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Jerry

4 months ago

I think it's E) Metformin.

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Delmy

5 months ago

Surprised to learn Metformin has that side effect!

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Vicky

5 months ago

Canagliflozin doesn't do that, right?

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Cletus

5 months ago

Really? I thought it was just a myth.

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Junita

5 months ago

Metformin is the one that can cause cyanocobalamin deficiency.

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Hyun

5 months ago

I'm feeling lucky, I'll go with C. Pioglitazone. Sounds like it could be a wild card.

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Gilberto

5 months ago

E. Metformin, no doubt. That stuff is like a vitamin-sucking vampire.

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Shalon

6 months ago

Haha, I bet the answer is D. Glimepiride, just to trick us all!

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Paris

6 months ago

I'm going with B. Canagliflozin, it just sounds like it could mess with your vitamins.

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Clay

6 months ago

I practiced a similar question last week, and it was definitely about Metformin causing B12 deficiency. I hope that helps!

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Kasandra

6 months ago

I’m not confident, but I feel like it could be one of the other options too. Did we cover any other medications that affect vitamin levels?

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Laticia

6 months ago

I remember something about Metformin and vitamin B12 deficiency from my notes. It seems to fit this question.

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Salome

6 months ago

Wait, I'm a bit confused. I thought pioglitazone was the one that could lead to B12 deficiency. Let me review my notes again.

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Kristeen

7 months ago

I'm pretty confident it's E) Metformin. That's the one I remember learning about causing cyanocobalamin issues.

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Cristal

7 months ago

I think Metformin is the one that can cause cyanocobalamin deficiency, but I'm not entirely sure.

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Lizbeth

7 months ago

Hmm, I think it's E. Metformin, that one always seems to cause issues.

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Michell

7 months ago

I've got a strategy - I'll eliminate the ones I'm sure don't cause B12 deficiency, then focus on the remaining options. Gotta use the process of elimination here.

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