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NABP NAPLEX Exam - Topic 5 Question 119 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 119
Topic #: 5

[All NAPLEX Questions]

Which of the following would be most appropriate to treat stenotrophomonas maltophilia?

AMeropenem

BVancomycin

CCiprofloxacin

DSulfamethoxazole/trimethoprim

ECefepime

Show Suggested Answer

Suggested Answer: D

Primary treatment for stenotrophomonas maltophilia is SMX-TMP. Meropenem, ciprofloxacin, and vancomycin have no coverage.

by Therese at May 04, 2026, 03:54 PM

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Cora

12 hours ago

Definitely not vancomycin, that’s for sure!

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Lenny

6 days ago

I thought meropenem was effective too?

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Noah

11 days ago

Sulfamethoxazole/trimethoprim is the go-to for S. maltophilia.

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Jerry

16 days ago

I recall that ciprofloxacin can be used for some resistant infections, but I’m leaning towards sulfamethoxazole/trimethoprim based on what we practiced.

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Margurite

2 months ago

I’m a bit confused about vancomycin. I know it’s for Gram-positive bacteria, but does it have any effect on Stenotrophomonas?

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Jerlene

2 months ago

I feel like sulfamethoxazole/trimethoprim was mentioned in a practice question about this organism. It might be the right choice.

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Amie

2 months ago

I think I remember that Stenotrophomonas maltophilia is often resistant to many antibiotics, but I’m not sure if meropenem is effective.

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