Discuss NABP NAPLEX Exam Topic 1 Question 24

Which of the following is recommended to be monitored in patients on Divalproex Sodium?

Suggested Answer: C

A, B, C. Hepatotoxicity, including hepatic failure, has been fatal and may more commonly occur in the first 6 months of treatment. Valproic acid and its analogs are contraindicated in patients with known urea cycle disorders. Patients with urea cycle disorders have a genetic enzyme defect leading to an impaired ability to produce urea. Hyperammonemic encephalopathy has been reported following initiation of valproate therapy. Because of, inhibition of the secondary phase of platelet aggregation, and abnormal coagulation parameters complete blood counts and coagulation tests are recommended before initiating valproic acid therapy and at periodic intervals.

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13 comments · newest first

Dianne 11 months ago

Wait, do we really need to check pulmonary function?

Elina 12 months ago

Agreed on LFT's, but surprised about ammonia too.

Peggy 12 months ago

I thought CBC was the main one to watch?

Dong 12 months ago

Serum ammonia is also important!

Kimberlie 1 year ago

Definitely need to monitor LFT's with Divalproex.

Maynard 1 year ago

I’m a bit confused about the pulmonary function monitoring; I don't recall that being a standard recommendation for Divalproex.

Carman 1 year ago

I practiced a question like this, and I feel like serum ammonia is also important to check, especially for signs of toxicity.

Margot 1 year ago

I remember something about monitoring LFTs because Divalproex can affect liver function, right?

Georgene 1 year ago

I think we need to monitor CBC for patients on Divalproex Sodium, but I'm not entirely sure if that's the most critical one.

Dyan 1 year ago

This looks like a straightforward email design question. I think the key is to make it as easy as possible for customers to provide feedback, so an interactive email form that links to a confirmation page seems like the best approach.

Eileen 1 year ago

This seems like a tricky one. I'll need to think it through carefully.

Chauncey 1 year ago

This requires careful calculation. I'll look for an option that seems mathematically aligned with the scenario's requirements.

Merissa 1 year ago

Hmm, I'm not totally sure about this one. Is it the product itself or the customer benefits? I'll have to think it through carefully.

NABP NAPLEX Exam - Topic 1 Question 24 Discussion