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What indication usually requires higher dose of proton pump inhibitor?
Suggested Answer: E
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The diagnosis of Zollinger-Ellison syndrome is suggested when plasma gastrin is > 1000 pg/ml and the basal acid output is > 15 mEq/h or when associated with a pH < 2. The treatment is focused on controlling gastric acid hypersecretion and localisation of the tumour and its metastases. Proton pump inhibitors are the most effective antisecretory drugs and can be administered at high dosages
11 comments · newest first
AL
Alida
11 months ago
Stress ulcer prophylaxis can also need higher doses sometimes.
MA
Malcolm
12 months ago
Wait, really? I didn't know that about Zollinger-Ellison!
CA
Carol
12 months ago
I thought esophagitis required more too?
HY
Hyun
12 months ago
Totally agree, that's a big one.
VI
Virgilio
1 year ago
Zollinger-Ellison syndrome needs higher doses!
TA
Tasia
1 year ago
I feel like duodenal ulcers usually get standard doses, but I could be wrong about that.
WI
Willard
1 year ago
Esophagitis sounds familiar for needing a higher dose, but I might be mixing it up with something else.
GA
Gayla
1 year ago
I remember practicing a question about stress ulcer prophylaxis, but I can't recall if it needs a higher dose or not.
HE
Helaine
1 year ago
I think Zollinger-Ellison syndrome might require a higher dose, but I'm not entirely sure.
FR
Francis
1 year ago
Hmm, the elbow plot shows a clear bend around 3 or 4 clusters, so I'd say those are good options to consider.
AD
Adrianna
1 year ago
Okay, let me see. The question is asking about a valid query, so I'll need to check the syntax and make sure the aggregation makes sense.