Secure Access Service Edge (SASE) is the technology best suited for preventing remote users from accessing malicious URLs. According to the CompTIA Security+ SY0-701 framework, SASE integrates cloud-native security capabilities such as DNS filtering, secure web gateways, CASB, and URL categorization, all delivered inline. This means every URL request from a remote user is checked in real time for reputation, content, and category before access is granted.

This solution is specifically designed for remote workforces because security enforcement happens in the cloud, regardless of user location---eliminating reliance on on-premise proxies or VPN routing. SASE also enables consistent policy application and real-time enforcement across distributed networks.

A VPN (A) only encrypts traffic; it does not perform URL reputation checks. IDS (C) detects malicious activity but does not block URL access. SD-WAN (D) optimizes WAN routing but is not focused on content filtering or URL reputation.

Therefore, SASE is the correct and most effective solution for inline URL inspection and preventing remote users from reaching malicious sites.