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ARDMS AB-Abdomen Exam - Topic 1 Question 8 Discussion

Actual exam question for ARDMS's AB-Abdomen exam
Question #: 8
Topic #: 1
[All AB-Abdomen Questions]

Elevation of alpha-fetoprotein levels is a characteristic finding in which tumor?

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Suggested Answer: A

Alpha-fetoprotein (AFP) is commonly elevated in patients with hepatocellular carcinoma (hepatoma), particularly in those with underlying cirrhosis or chronic hepatitis B/C. AFP is not typically elevated in adenomas, cholangiocarcinoma, or FNH.

According to Rumack's Diagnostic Ultrasound:

''Serum AFP levels are elevated in 50--70% of patients with hepatocellular carcinoma.''


Rumack CM, Wilson SR, Charboneau JW, Levine D. Diagnostic Ultrasound. 5th ed. Elsevier, 2017.

AASLD Guidelines for HCC Surveillance, 2018.

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by Elly at Jan 29, 2026, 05:03 AM

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Joseph
15 days ago
I think it's liver cancer.
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Annmarie
20 days ago
I heard it can be elevated in pregnancy too!
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Chan
25 days ago
Yup, definitely liver and testicular cancers.
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Silva
1 month ago
Wait, really? I thought it was just liver-related.
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Tricia
1 month ago
Totally agree, also seen in germ cell tumors!
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Brigette
1 month ago
It's associated with liver cancer.
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Carole
2 months ago
Liver cancer, duh. Although I'd rather have a nice steak than a tumor any day.
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Kristeen
2 months ago
Isn't alpha-fetoprotein linked to pregnancy? I'm stumped on this one.
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Lindsey
2 months ago
Hmm, I'm pretty sure it's testicular cancer. Gotta love those weird tumor markers!
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Sophia
2 months ago
This one's a no-brainer, it's gotta be liver cancer.
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Pamella
2 months ago
I’m a bit confused... I thought it could also be related to testicular cancer, but I guess hepatocellular carcinoma is the classic answer?
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Isabelle
2 months ago
I practiced a question like this before, and I feel like it was definitely linked to liver cancer. Just can’t recall the specifics!
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Raina
3 months ago
I remember something about it being elevated in germ cell tumors too, but I’m not sure if that’s the main one they’re looking for.
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Winfred
3 months ago
I think alpha-fetoprotein is mainly associated with liver tumors, right? Maybe hepatocellular carcinoma?
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Ming
4 months ago
Hmm, I'm a bit stuck on this one. I know alpha-fetoprotein is associated with certain cancers, but I can't quite remember which one. I'll have to try to eliminate some options and see if I can narrow it down.
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Fausto
4 months ago
I've got this! Alpha-fetoprotein is elevated in hepatocellular carcinoma, which is a type of liver cancer. I'm confident that's the right answer.
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Clay
4 months ago
Ugh, I'm really not sure about this one. Tumor markers are not my strongest area. I'll have to make an educated guess and hope for the best.
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Jeannine
4 months ago
Okay, let me see... alpha-fetoprotein is a fetal protein, so it's likely related to a type of cancer that originates from fetal or embryonic tissue. I'm going to start by considering germ cell tumors.
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Bok
4 months ago
Hmm, this seems like a question about tumor markers. I'll need to think through the different types of tumors and their associated biomarkers.
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