For enabling jumbo frames on Cisco Nexus switches for NVMe over TCP with tagged VLANs, the following changes are required:

Modify the Cisco Nexus switches to use an MTU of 9216: Setting the MTU to 9216 ensures that the network can handle jumbo frames, reducing the number of packets needed for large data transfers and thus improving performance.

Modify the appropriate broadcast domain in NetApp ONTAP software to use an MTU of 9216: This setting must match the network configuration to ensure end-to-end support for jumbo frames, which is essential for optimizing performance in NVMe over TCP environments.

For additional information, refer to:

NetApp Documentation on NVMe over TCP

Cisco Documentation on Jumbo Frames