NABP FPGEE Exam - Topic 6 Question 94 Discussion

Actual exam question for NABP's FPGEE exam

Question #: 94
Topic #: 6

In an adequately powered, randomized controlled trial conducted over 2 years, the desired clinical outcome (i.e. prevention of a serious cardiovascular event) with a new drug is achieved in 25% of the study sample. In the patients who receive a placebo, only 15% obtain the same clinical benefit. The relative risk reduction achieved with the new drug over the study period is:

A10%.

B15%.

C25%.

D40%.

E50%.

Show Suggested Answer

Suggested Answer: B

by Kiley at Sep 13, 2024, 06:31 PM

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Lauran

6 months ago

I thought it would be higher, honestly.

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Pearly

6 months ago

Totally agree, 10% makes sense with those numbers!

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Margret

6 months ago

Wait, how is it only 10%? Seems low for a new drug.

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Kenneth

7 months ago

That’s a 10% relative risk reduction!

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Bernardine

7 months ago

The new drug has a 25% success rate, placebo is 15%.

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Frederica

7 months ago

I think the relative risk reduction is calculated as (control event rate - treatment event rate) / control event rate. So maybe it's 50%?

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Gail

7 months ago

I feel like the answer might be around 40%, but I can't recall the exact formula we used for relative risk reduction.

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Tamra

7 months ago

This reminds me of a practice question where we had to find the difference in event rates. I think we subtract the placebo rate from the treatment rate first.

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Cary

8 months ago

I remember we calculated relative risk reduction in class, but I'm not entirely sure how to apply it here.

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Gerardo

8 months ago

Wait, I'm confused. Isn't the relative risk reduction supposed to be a percentage? How do I convert this to a percentage?

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Natalie

8 months ago

No problem, I've got this. The relative risk reduction is just (control event rate - treatment event rate) / control event rate. So it's (15% - 25%) / 15% = 40%.

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Devorah

8 months ago

I'm a little unsure about how to calculate the relative risk reduction here. Do I need to do some kind of statistical test or can I just do a simple calculation?

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Dorathy

8 months ago

Hmm, this seems straightforward enough. I just need to plug the numbers into the formula for relative risk reduction and see which answer choice matches.

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Phyliss

8 months ago

Okay, let me think this through. The question is asking for the relative risk reduction, which is the difference in the event rates between the treatment and placebo groups. I need to calculate that based on the given information.

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Tambra

1 year ago

Ugh, I knew this one would be tricky. At least I can eliminate the wrong answers and narrow it down. Relative risk reduction, not absolute risk - got it, thanks Yuonne!

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Samuel

11 months ago

D) 40%.

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Audry

11 months ago

C) 25%.

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Ozell

11 months ago

B) 15%.

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Marg

11 months ago

A) 10%.

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Altha

1 year ago

I was going to say E) 50%, but now I see my mistake. Relative risk reduction is not the same as absolute risk reduction. Silly me, I should have paid more attention in class.

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Jamal

1 year ago

Definitely D) 40%. I'm glad I reviewed the relative risk reduction concept before the exam. It's a common question type in these kinds of trials.

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Pamella

11 months ago

D) 40%.

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Xenia

12 months ago

C) 25%.

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Skye

12 months ago

B) 15%.

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Deonna

12 months ago

A) 10%.

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Elvis

1 year ago

I was thinking the same, Yuonne. The relative risk reduction formula is straightforward, and the numbers provided make it a simple calculation.

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Denise

12 months ago

C) 25%

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Jaclyn

12 months ago

B) 15%

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Timothy

1 year ago

A) 10%

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Yuonne

1 year ago

I think the answer is D) 40%. The relative risk reduction is the difference in the event rate between the treatment and placebo groups, divided by the event rate in the placebo group. In this case, it's (25% - 15%) / 15% = 0.4 or 40%.

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