Discuss NABP FPGEE Exam Topic 3 Question 118

When evaluating patients with angina for possible development of nitrate tolerance, true statements include:

I tolerance is rarely associated with isosorbide dinitrate.

II tolerance does not occur in patients who are concurrently on

metoprolol.

III tolerance is dependent upon the administration schedule of nitrate medication.

Suggested Answer: B

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21 comments · newest first

Bulah 1 month ago

I feel like I and II could be misleading. C might be safer.

Tyra 1 month ago

I’m with B. The timing of nitrate doses is crucial for tolerance.

Avery 1 month ago

E seems too broad. I think we need to focus on specific cases.

Dahlia 2 months ago

I lean towards D. Metoprolol might change how tolerance develops.

Stanford 2 months ago

I agree, but I feel like C makes sense too. Isosorbide dinitrate is tricky.

Pura 2 months ago

I think B is the best choice. Tolerance really depends on how you schedule nitrates.

Cheryl 2 months ago

I’m confused. Why isn’t I more significant? It feels important in this context.

Hillary 2 months ago

I think D makes sense. II and III seem valid together. Metoprolol might help.

Jamal 2 months ago

I feel like A is the safest choice. I tolerance is rarely linked to isosorbide dinitrate.

Bulah 3 months ago

I’m leaning towards E. I, II, and III. All statements have some truth to them.

Sophia 3 months ago

I agree with you, Alverta. The timing of nitrates is crucial.

Alverta 3 months ago

I think the answer is B. III only. Tolerance really depends on how we schedule the doses.

Ben 3 months ago

I’m leaning towards III only, seems most accurate.

Isadora 3 months ago

I think I remember tolerance being a bigger issue overall.

Chara 4 months ago

Wait, are you saying metoprolol prevents tolerance? That’s new to me.

Lezlie 5 months ago

Totally agree, the schedule really matters for tolerance!

Alana 5 months ago

I thought tolerance was common with isosorbide dinitrate.

Edison 6 months ago

I’m leaning towards option B because I think tolerance is mostly about how you take the medication, but I’m not entirely confident.

Milly 6 months ago

I feel like we talked about the importance of the administration schedule for nitrates affecting tolerance. That might be key here.

Jodi 6 months ago

I think we practiced a question about tolerance and beta-blockers, but I can't recall if metoprolol completely prevents it.

Kris 6 months ago

I remember discussing nitrate tolerance in class, but I'm not sure if isosorbide dinitrate is really that different from other nitrates.

NABP FPGEE Exam - Topic 3 Question 118 Discussion