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NABP FPGEE Exam - Topic 3 Question 118 Discussion

When evaluating patients with angina for possible development of nitrate tolerance, true statements include:I tolerance is rarely associated with isosorbide dinitrate.II tolerance does not occur in patients who are concurrently onmetoprolol.III tolerance is dependent upon the administration schedule of nitrate medication.
B) III only
A) I only
C) I and II only
D) II and III only
E) I, II and III

NABP FPGEE Exam - Topic 3 Question 118 Discussion

Actual exam question for NABP's FPGEE exam
Question #: 118
Topic #: 3
[All FPGEE Questions]

When evaluating patients with angina for possible development of nitrate tolerance, true statements include:

I tolerance is rarely associated with isosorbide dinitrate.

II tolerance does not occur in patients who are concurrently on

metoprolol.

III tolerance is dependent upon the administration schedule of nitrate medication.

Show Suggested Answer Hide Answer
Suggested Answer: B

by Reena at Apr 13, 2026, 02:46 AM

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Alverta
2 hours ago
I think the answer is B. III only. Tolerance really depends on how we schedule the doses.
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Ben
5 days ago
I’m leaning towards III only, seems most accurate.
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Isadora
10 days ago
I think I remember tolerance being a bigger issue overall.
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Chara
16 days ago
Wait, are you saying metoprolol prevents tolerance? That’s new to me.
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Lezlie
2 months ago
Totally agree, the schedule really matters for tolerance!
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Alana
2 months ago
I thought tolerance was common with isosorbide dinitrate.
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Edison
3 months ago
I’m leaning towards option B because I think tolerance is mostly about how you take the medication, but I’m not entirely confident.
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Milly
3 months ago
I feel like we talked about the importance of the administration schedule for nitrates affecting tolerance. That might be key here.
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Jodi
3 months ago
I think we practiced a question about tolerance and beta-blockers, but I can't recall if metoprolol completely prevents it.
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Kris
3 months ago
I remember discussing nitrate tolerance in class, but I'm not sure if isosorbide dinitrate is really that different from other nitrates.
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