E) Desipramine: enhances analgesia? Really? I didn't know Demerol and antidepressants could have that kind of interaction. Learn something new every day!
C) Amiodarone: inhibits activation seems like the right answer to me. Amiodarone is a potent inhibitor of certain liver enzymes, which could reduce the conversion of Demerol to its active form.
I think the correct answer is D) Phenytoin: stimulates metabolism. Demerol is broken down by the liver, and Phenytoin is known to increase the activity of liver enzymes, leading to faster metabolism of Demerol.
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