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You have the following:
A Microsoft 365 E5 tenant
An on-premises Active Directory domain
A hybrid Azure Active Directory (Azure AD) tenant
An Azure Active Directory Domain Services (Azure AD DS) managed domain
An Azure Virtual Desktop deployment
The Azure Virtual Desktop deployment contains personal desktops that are hybrid joined to the on-premises domain and enrolled in Microsoft Intune.
You need to configure the security settings for the Microsoft Edge browsers on the personal desktops.
Solution: You configure a compliance policy in Intune.
Does this meet the goal?
You need to configure a Configuration Profile in Intune or use Group Policy.