When configuring the system proxy for FortiSOAR, it is essential to ensure connectivity to certain URLs to maintain system updates and licensing. For FortiSOAR, access to https://iepo.fortisoar.fortinet.com is required for incident enrichment and analysis, while https://globalupdate.fortinet.net is necessary for global updates to keep the system up-to-date with the latest threat information. These connections allow FortiSOAR to communicate with Fortinet's servers to fetch updated threat intelligence and system updates, which are critical for the operational effectiveness of FortiSOAR.