The Cisco Endpoint IoC feature is a powerful incident response tool for scanning of post-compromise indicators across multiple computers. Endpoint IoCs are imported through the console from OpenIOC-based files written to trigger on file properties such as name, size, hash, and other attributes and system properties such as process information, running services, and Windows Registry entries. The IoC syntax can be used by incident responders to find specific artifacts or use logic to create sophisticated, correlated detections for families of malware. Endpoint IoCs have the advantage of being portable to share within your organization or in industry vertical forums and mailing lists. The Endpoint IoC scanner is available in AMP for Endpoints Windows Connector versions 4 and higher. Running Endpoint IoC scans may require up to 1 GB of free drive space. The Endpoint IoC feature is based on the openioc.com framework, which is an open standard for sharing threat intelligence.Reference:

Cisco Endpoint IOC Attributes, User Guide

What Are Indicators of Compromise (IOC)? - Cisco, Security Indicators of Compromise

General questions about AMP - Cisco Community, Post by Cisco Employee

The Endpoint Indication of Compromise (IOC) feature is a powerful incident response tool for scanning of post-compromise indicators across multiple computers.